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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Félix Hernández SP | 16 | 5 | 0 | 2.33 | 32 | 32 | 220.1 | 178 | 61 | 57 | 10 | 52 | 236 | 1.04 | .221 | .298 | 8.8 |
| Chris Colbert SP | 0 | 1 | 1 | 3.83 | 33 | 0 | 42.1 | 32 | 19 | 18 | 6 | 20 | 48 | 1.23 | .213 | .268 | 0.3 |
| Jesús Flores RP | 3 | 5 | 3 | 3.90 | 49 | 0 | 57.2 | 46 | 26 | 25 | 7 | 39 | 63 | 1.47 | .218 | .277 | 0.0 |
| Bill Lund RP | 3 | 3 | 0 | 3.95 | 38 | 0 | 68.1 | 53 | 30 | 30 | 13 | 26 | 64 | 1.16 | .215 | .235 | -0.1 |
| Steve Neal RP | 3 | 2 | 17 | 4.23 | 65 | 0 | 66.0 | 67 | 35 | 31 | 12 | 19 | 69 | 1.30 | .264 | .318 | 0.4 |
| Adam McPherson SP | 10 | 12 | 0 | 4.96 | 33 | 33 | 203.1 | 214 | 113 | 112 | 27 | 63 | 144 | 1.36 | .273 | .301 | 2.5 |
| Jorge González RP | 1 | 3 | 1 | 4.99 | 36 | 0 | 30.2 | 32 | 17 | 17 | 8 | 12 | 22 | 1.43 | .269 | .267 | -0.6 |
| Ernest Williams RP | 9 | 8 | 16 | 5.01 | 65 | 0 | 70.0 | 69 | 39 | 39 | 18 | 29 | 91 | 1.40 | .255 | .315 | -0.5 |
| Matt Mathieu SP | 7 | 12 | 0 | 5.19 | 32 | 32 | 185.2 | 191 | 112 | 107 | 38 | 59 | 132 | 1.35 | .267 | .278 | 0.6 |
| George Owens RP | 0 | 2 | 0 | 5.23 | 38 | 1 | 74.0 | 90 | 45 | 43 | 14 | 19 | 58 | 1.47 | .311 | .342 | -0.1 |
| Mike Sykes SP | 9 | 18 | 0 | 5.24 | 32 | 32 | 178.2 | 195 | 107 | 104 | 33 | 72 | 131 | 1.49 | .277 | .298 | 0.3 |
| Ángelo Longoria SP | 0 | 2 | 1 | 5.30 | 19 | 0 | 18.2 | 24 | 11 | 11 | 3 | 6 | 16 | 1.61 | .312 | .350 | 0.1 |
| Bartolo Bojórquez SP | 7 | 19 | 0 | 5.63 | 32 | 32 | 188.2 | 227 | 124 | 118 | 34 | 59 | 144 | 1.52 | .300 | .329 | 1.3 |
| Xavier Gonzáles RP | 1 | 1 | 1 | 8.40 | 26 | 0 | 30.0 | 33 | 28 | 28 | 5 | 23 | 26 | 1.87 | .275 | .315 | -0.5 |
