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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Matt Pruitt# | 488 | 2036-2049 | |
| 2 | Miguel Sánchez | 460 | 2032-2045 | |
| 3 | Jake Reeves | 439 | 2028-2049 | |
| 4 | Miguel Serna* | 376 | 2025-2039 | |
| 5 | John Conway | 372 | 2033-2046 | |
| 6 | Jesse Callahan# | 342 | 2033-2049 | |
| 7 | Jesús Cruz# | 312 | 2036-2049 | |
| 8 | Pedro Zavala# | 296 | 2031-2049 | |
| 9 | Dave Parker | 274 | 2026-2037 | |
| 10 | Chris Olson# | 269 | 2037-2048 | |
| 11 | Enzo Díaz | 268 | 2016-2035 | |
| 12 | Juan Castro | 260 | 2017-2032 | |
| 13 | Kenny Shaffer# | 259 | 2039-2048 | |
| 14 | Mike Martínez | 244 | 2032-2043 | |
| 15 | Howard Evans | 235 | 2027-2040 | |
| 16 | Manolo Román | 233 | 2017-2029 | |
| 17 | Bill Seath# | 226 | 2040-2049 | |
| 18 | Vic Langlois | 211 | 2024-2038 | |
| 19 | Miguel González | 210 | 2016-2029 | |
| 20 | Lee Kitchener | 209 | 2034-2042 | |
| 21 | Anastasio Villa | 208 | 2028-2037 | |
| 22 | Víctor Cuevas | 207 | 2033-2045 | |
| 23 | Jorge Jiménez | 204 | 2025-2038 | |
| 24 | Arturo Sánchez | 200 | 2027-2039 | |
| 25 | Jesús Ramírez | 192 | 2016-2029 | |
| 26 | Sergio Márquez | 191 | 2021-2042 | |
| 27 | Shane Hutchinson* | 182 | 2023-2042 | |
| 28 | Jesús Espinoza | 178 | 2024-2034 | |
| 29 | Félix Morales | 174 | 2013-2021 | |
| 30 | Matt Lehman | 169 | 2036-2048 | |
| 30 | Wesley Weaver | 169 | 2007-2013 | |
| 32 | Javier Villegas | 168 | 2018-2027 | |
| 33 | Louis May | 151 | 2007-2020 | |
| 34 | Iván Gonzáles | 149 | 2023-2035 | |
| 35 | José López# | 147 | 2037-2049 | |
| 36 | Anacleto Morillo | 141 | 2018-2030 | |
| 37 | Lonnie Anderson | 140 | 2024-2037 | |
| 37 | David Paquette | 140 | 2007-2015 | |
| 39 | Jud Younger | 138 | 2013-2023 | |
| 39 | Jorge Zambrano | 138 | 2012-2023 | |
| 41 | Héctor Núñez | 133 | 2010-2025 | |
| 42 | Austin Clark# | 122 | 2043-2049 | |
| 42 | Mike Harris | 122 | 2035-2042 | |
| 42 | Enrique Jaramillo | 122 | 2009-2016 | |
| 42 | Matt Smith | 122 | 2022-2031 | |
| 46 | Antenor Anchieta | 120 | 2035-2047 | |
| 47 | Mathew Clayton | 119 | 2029-2042 | |
| 48 | Phil Jones# | 115 | 2045-2049 | |
| 49 | Jack Cook# | 113 | 2043-2049 | |
| 49 | Ben Moss | 113 | 2013-2025 | |
| 51 | Guillermo Vega | 112 | 2009-2015 | |
| 52 | Juan Carlos Rodríguez | 110 | 2020-2035 | |
| 53 | Pepe Carrasco | 108 | 2016-2035 | |
| 53 | Michael Keller | 108 | 2032-2044 | |
| 53 | Philip Patterson | 108 | 2007-2015 | |
| 56 | Jeff Jones | 107 | 2028-2035 | |
| 57 | Roberto Sandoval | 106 | 2025-2034 | |
| 58 | David Peña | 105 | 2010-2021 | |
| 59 | Rudy Butler# | 104 | 2042-2047 | |
| 60 | Raúl Mejía | 102 | 2038-2047 | |
| 60 | Juan Romero | 102 | 2028-2035 | |
| 62 | Peter Bishop | 101 | 2029-2041 | |
| 62 | Riley Cassidy | 101 | 2007-2020 | |
| 62 | Masanobu Hasegawa | 101 | 2009-2019 | |
| 62 | Evan Keeler | 101 | 2007-2013 | |
| 62 | Michael Wallace | 101 | 2036-2041 | |
| 67 | Damon Mitchell | 99 | 2016-2026 | |
| 67 | John Rodmell | 99 | 2039-2047 | |
| 69 | Wilson López | 98 | 2016-2029 | |
| 69 | Yifu Tsui# | 98 | 2047-2049 | |
| 71 | Ramón Hernández | 94 | 2014-2023 | |
| 72 | Luis Alou | 93 | 2013-2026 | |
| 73 | Max Rash | 91 | 2024-2035 | |
| 74 | Mike Brown# | 90 | 2042-2049 | |
| 75 | Flint Ballard | 89 | 2034-2042 | |
| 75 | Bartolo Yamaguchi | 89 | 2039-2048 | |
| 77 | Francisco Sandoval | 88 | 2021-2036 | |
| 78 | Aaron Hernández | 87 | 2037-2043 | |
| 79 | Rich Ruffin | 85 | 2017-2029 | |
| 80 | Tom Duffy | 84 | 2038-2044 | |
| 80 | José Salazar | 84 | 2021-2035 | |
| 80 | Lawrence Schroeder | 84 | 2016-2030 | |
| 83 | José Borrero# | 79 | 2035-2049 | |
| 83 | Larry Good | 79 | 2035-2046 | |
| 83 | Gerben Illidge | 79 | 2007-2013 | |
| 83 | Pancho Montoya# | 79 | 2042-2049 | |
| 83 | Parker Morrow | 79 | 2007-2018 | |
| 88 | Moo-hyun Pak | 77 | 2013-2021 | |
| 89 | Robby Lewis | 75 | 2026-2033 | |
| 90 | Nassir Abiola | 73 | 2010-2014 | |
| 90 | Bryan Curtis# | 73 | 2046-2049 | |
| 92 | Naomi Kitamura | 72 | 2016-2026 | |
| 93 | Harley Pope# | 71 | 2046-2049 | |
| 93 | Ienobu Suzuki# | 71 | 2042-2049 | |
| 93 | Abdu Tabari | 71 | 2037-2041 | |
| 96 | Alejandro De Jesús# | 70 | 2044-2049 | |
| 97 | John Pinksen | 69 | 2007-2010 | |
| 97 | Jerome Shepherd | 69 | 2007-2012 | |
| 99 | Manny Garza# | 67 | 2039-2044 | |
| 100 | Marc-André Dumont | 65 | 2015-2023 |
