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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Jesús Cervantes | 0.733 | 2028 | |
| 2 | Pat Hardy | 1.221 | 2028 | |
| 3 | Francisco López | 1.262 | 2027 | |
| 4 | Dave Cardona# | 1.445 | 2042 | |
| 5 | Harry Robinson | 1.456 | 2028 | |
| 6 | Keith O'Higgins | 1.494 | 2029 | |
| 7 | Ramón Cardenas | 1.531 | 2027 | |
| 8 | Reginald Clay# | 1.739 | 2042 | |
| 9 | Josh Young | 1.746 | 2026 | |
| 10 | Álex Yan# | 1.757 | 2042 | |
| 11 | Millard Manning | 1.835 | 2027 | |
| 12 | Luis Rincón | 1.908 | 2032 | |
| 13 | César Ohayashi | 1.929 | 2033 | |
| 14 | Frederico White# | 1.936 | 2038 | |
| 15 | Tomás Muñóz | 1.938 | 2026 | |
| 16 | Brian Hodges | 1.966 | 2026 | |
| 17 | Kevin Jenkins | 1.967 | 2040 | |
| 18 | José Fernández | 1.982 | 2026 | |
| 19 | Clarence Holmes | 1.988 | 2028 | |
| 20 | Dan Catron | 1.991 | 2027 | |
| 21 | Jorge Sierra | 2.008 | 2028 | |
| 22 | Paolo Torrigiano | 2.068 | 2033 | |
| 23 | Pedro Gonzáles | 2.099 | 2034 | |
| 24 | Whit Hart# | 2.124 | 2042 | |
| 25 | Jorge Chávez | 2.139 | 2028 | |
| 26 | Jordan Bagnall# | 2.174 | 2042 | |
| 27 | Walt McCarthy# | 2.241 | 2038 | |
| 28 | Bezzi Kisito | 2.276 | 2030 | |
| 29 | Javier Pérez | 2.278 | 2032 | |
| 30 | William Evans | 2.292 | 2029 | |
| 31 | Scott Ramón | 2.298 | 2031 | |
| 32 | Mike Fitzpatrick | 2.300 | 2031 | |
| 33 | Luis Reyes | 2.305 | 2029 | |
| 34 | Vicente Calderón | 2.328 | 2026 | |
| 35 | Dave MacLardie | 2.353 | 2030 | |
| 36 | Ron Moore | 2.372 | 2026 | |
| 37 | José García# | 2.379 | 2037 | |
| 38 | Beau Wills# | 2.386 | 2049 | |
| 39 | Carlos González | 2.412 | 2036 | |
| 40 | Alonso Mendoza | 2.416 | 2028 | |
| 41 | Sam Olson | 2.431 | 2026 | |
| 42 | Jorge Guillén | 2.455 | 2026 | |
| 42 | Al Harrison | 2.455 | 2032 | |
| 42 | Tomás Prieto | 2.455 | 2028 | |
| 45 | Carl Orr | 2.484 | 2031 | |
| 46 | Gerardo González | 2.502 | 2026 | |
| 47 | Terry Hoffman | 2.527 | 2030 | |
| 48 | Willem Guerin | 2.535 | 2035 | |
| 49 | Daron Chandler# | 2.585 | 2032 | |
| 50 | Ron Young# | 2.594 | 2042 | |
| 51 | Franklyn DeMars | 2.605 | 2034 | |
| 51 | Orlando Peña | 2.605 | 2029 | |
| 53 | Thomas Brown# | 2.623 | 2043 | |
| 54 | Rien Middelkamp | 2.640 | 2026 | |
| 55 | Juan Suárez | 2.668 | 2029 | |
| 56 | Javier González | 2.673 | 2034 | |
| 57 | Phil Pearson# | 2.679 | 2039 | |
| 57 | Brian Lovelace | 2.679 | 2029 | |
| 59 | Guillermo Quiñones | 2.688 | 2029 | |
| 59 | Luis Díaz# | 2.688 | 2041 | |
| 61 | Christiano Bray | 2.700 | 2028 | |
| 61 | John Jorgensen | 2.700 | 2027 | |
| 63 | Jesús Núñez | 2.712 | 2029 | |
| 64 | Nestore Baroncelli | 2.732 | 2031 | |
| 65 | Bai-luo Li | 2.733 | 2033 | |
| 66 | Steve Sousa | 2.736 | 2027 | |
| 67 | Víctor Hernández | 2.741 | 2026 | |
| 68 | Mel Oliver# | 2.743 | 2037 | |
| 69 | Jesús Sánchez | 2.751 | 2026 | |
| 70 | Larry Johnston | 2.752 | 2026 | |
| 71 | Eduardo López | 2.755 | 2031 | |
| 72 | Craig Scott | 2.764 | 2031 | |
| 73 | Jimmy Hahn# | 2.768 | 2042 | |
| 74 | Bill Riggs# | 2.774 | 2040 | |
| 75 | Héctor Ramos | 2.790 | 2033 | |
| 76 | Desi Riley# | 2.800 | 2041 | |
| 77 | Tim Sanders | 2.815 | 2029 | |
| 78 | Jorge Marino# | 2.828 | 2048 | |
| 79 | Les Johnston | 2.835 | 2027 | |
| 80 | José Gómez# | 2.845 | 2039 | |
| 81 | Charlie McCarthy# | 2.848 | 2042 | |
| 82 | Kyle Horton | 2.860 | 2027 | |
| 83 | Rodrigo Torres | 2.879 | 2031 | |
| 84 | Vicente Calderón | 2.880 | 2027 | |
| 85 | Dan Perkins# | 2.886 | 2042 | |
| 86 | Michael MacAulay | 2.887 | 2038 | |
| 87 | Calogero DeLaurentiis | 2.888 | 2030 | |
| 88 | David Icaza# | 2.899 | 2038 | |
| 89 | Gordon McBride | 2.906 | 2038 | |
| 90 | Mike Drake | 2.908 | 2029 | |
| 91 | Claudio Cuevas | 2.912 | 2032 | |
| 92 | Jérémy Bailleul | 2.915 | 2032 | |
| 93 | Juan Salazar | 2.916 | 2030 | |
| 94 | Walt McCarthy# | 2.919 | 2037 | |
| 95 | Carlos López | 2.929 | 2030 | |
| 96 | Diego Martínez# | 2.941 | 2037 | |
| 96 | Doug Johnston | 2.941 | 2029 | |
| 98 | José Hernández | 2.957 | 2028 | |
| 99 | Gustavo Acevedo | 2.961 | 2033 | |
| 100 | Raúl Vélez | 2.963 | 2032 |
